Diabetes is a disease that occurs due to cell cell-mediated autoimmune attack against pancreatic cells.

A study reveals that patients with Type I Diabetes Mallitus were diagnosed by clinical findings and hyperglycemia and confirmed with positive antibodies against glutamic acid decarboxylase.

Most patients became insulin free with normal levels of glycated hemoglobin after follow-ups. To investigate if this effect was due to preservation of beta-cell mass, continued monitoring was performed of C-peptide levels after stem cell transplantation.

C-level peptide measured during the test, before and at different times following HSCT. Morbidity and mortality from transplantation and temporal changes exogenous habits of insulin requirements (daily dose and duration of usage) at “Bone Marrow Transplantation unit of School of Medicine of Ribeirão Preto, Ribeirão Preto, Brazil”.

During 7 to 36-months follow-up, patients became insulin-free, but the conditions varied from a person to a person. Among those, 1 patient resumed insulin use 1 year after AHST. At 6 months after AHST, mean total area under the C-peptide response curve was significantly greater than the pretreatment values, and at 12 and 24 months it did not change. Anti–glutamic acid decarboxylase antibody levels decreased after 6 months and stabilized. Serum levels of hemoglobin were maintained at less than 7%.

After a mean follow-up months following autologous nonmyeloablative HSCT in patients with newly diagnosed type 1 DM, C-peptide levels increased significantly and the majority of patients achieved insulin independence with good glycemic control.